A Research on Comparative Study of Floating Tablets of Theophylline Utilizing Different Techniques
Sujan Neupane, Milan Subedi, Shona Kadel, Sheeba FR
Published: September 07, 2021.
Abstract
The primary intention of the present work is to fabricate the floating tablets of theophylline employing various methodologies of formulation and to execute the comparative study between the formulations developed by different techniques. Theophylline when used in a lower concentration act as an anti-inflammatory drug, when developed as a floating tablet it reduces the frequency of drug administration as it remains buoyant in the gastric contents and release the drug at a pre-determined rate. Different methods are utilized for the formulation of the floating tablets with an intention to prolong gastric residence time and reduction in inconstancy of the drug. Theophylline, a xanthine derivative bronchodilator is used as a model drug and three different techniques were accustomed viz, direct compression effervescent technique, non-aqueous wet granulation technique and solvent evaporation technique. Sodium bicarbonate and tartaric acid were used as gas generating agent whereas HPMC 15cps and sodium alginate as polymers. Twelve formulations were fabricated using three techniques, i.e. four formulations of each technique. All the prepared formulations were evaluated as prescribed by the Pharmacopoeial monograph for tablets. The optimized formulation DF2 showed a drug release of 70.225±0.888 at the end of 8 hours with a floating lag time of 08.4 sec and remains buoyant for more than 8 hours. Among the three different techniques, direct compression effervescence technique can be successfully employed for the development of floating tablets of Theophylline. The obtained data were subjected only for descriptive analysis.
Keywords: Theophylline; Direct compression effervescent technique; Non-aqueous wet granulation technique; Solvent evaporation technique