Nowadays scientists pay special attention to the fact that all engineering tasks should be set and solved from the standpoint of combating climate change by reducing greenhouse gas emissions. The proposed and used materials and technologies should have a low carbon footprint and comply with the principles of developing a green economy.

Introduction. The article evaluates the special role of Small and medium-sized enterprises (SMEs) in the development of the economy both in Europe and Georgia. On the other hand, the need to introduce and develop framework conditions for sustainable development to achieve long-term economic well-being is emphasized. Georgia's full-fledged integration into the European and Euro-Atlantic space requires rapid economic development of the country, using economic policy tools to create additional incentives for production development. SMEs can contribute the most to the rapid recovery and development of the economy, especially to poverty alleviation. Their role is also important in growth in the diversification of exports, the introduction of innovations, creating the modern Entrepreneurial culture, and more.

Aim and tasks. The main purpose of the article is to highlight the main challenges and opportunities for promoting sustainable development in SMEs in Georgia. To achieve this goal foreign experience in different countries in terms of stimulating sustainable development has been studied. The sustainable development of SMEs in Georgia and EU countries is compared.

Research results. The paper defines the conditions for sustainable development in SMEs. The article also establishes the impact of Covid 19 on the implementation of the sustainable development goals of enterprises. In the paper, the main challenges of sustainable development and opportunities for stimulation are investigated with the following methodology: bibliographic research is conducted; Analysis, comparison, induction, and other methods are used; Quantitative and qualitative research has been conducted. The focus of the research is the sector of agriculture and the firms operating in this field.

Conclusions. Conclusions are made on SMEs' main barriers to sustainable development and digital transformation (DX). Recommendations are offered on overcoming challenges and implementing opportunities for stimulation.

Keywords: Small and medium-sized enterprises; Sustainable development; Barriers to sustainable development; Promoting sustainable development; Economic policy

Introduction: Tuberculosis is an infection caused by Mycobacterium tuberculosis. Its extrapulmonary forms are numerous.

Method: This was a prospective descriptive study, lasting four years, from 1 February 2019 to 31 January 2023, carried out in the paediatric department of the CHU Donka. Our study variables were epidemiological, diagnostic and therapeutic.

Results: During our period, we counted 27 patients. The age group 11-15 years was most represented 40.74%, with an average age of 8.4 years. The male sex was the most represented 62.96% with a sex ratio of 1.7. Fever largely dominated the reasons for consultation, 70.37%. Eighteen (18) patients out of 25 had been vaccinated with BCG (66.67%). The TST and GeneXpert were very decisive in the diagnosis and meningeal tuberculosis dominated the picture (22.22%). Our patients were all treated with anti-tuberculosis drugs and the evolution was favourable (77.78%), 5 patients had died (18.52%).

Conclusion: Tuberculosis remains a significant pathology in our department despite BCG vaccination at birth.

Keywords: Extapulmonary tuberculosis; Pediatrics; CHU Donka; Guinea-Conakry

     Although largely confined to Western countries in the past, breast cancer incidence is increasing also in developing countries. Recent rise in Asia breast cancer has seemed weighted toward the both young and elderly. If caught in early stages, breast cancer can be treated effectively. If caught late, it is often fatal.

     Breast cancer can present with lump that feels different from the rest of the breast tissue, swelling of the breast, nipple discharge, rash on the nipple, and pain in the breast.

     Knowledge among the general public has not risen as fast as incidence in the developing areas. There are lack of health education and misunderstanding.

     Breast cancer often present in late stage in developing countries and causes stigma.

     Early diagnosis is important. If identified early, cancer is more likely to respond to effective treatment with greater probability of surviving, less morbidity, and less expensive treatment.

Bimaxillary protrusion is a commonly seen deformity in Asian populations. This condition is characterized by protusive and proclined upper and lower incisors and incompetence of lips, gummy smile, mentalis muscle strain and anterior open bite [1]. This condition poses a serious threat to the aesthetic concern of the patient which is interwined with psychological trauma and social inter-relation disturbances. A Successful treatment depends on the thorough evaluation of the condition, understanding the need and the concern of the patient and providing an appropriate treatment plan. This case report describes correcting a bimaxillary protrusion by treating the upper anteriors with Root Canal Treatment, placing a post and core with change in the angle of inclination and restoring them with a crown & bridge prosthesis.

Dental implants play a very important role in dentistry. A very careful diagnosis and treatment planning must be followed to grant a successful outcome. It must be taken into consideration the challenges of oral cavity and its anatomical structures and in the maxilla, the maxillary sinus is the most important in this situation.
Keywords: dental implant; maxillary sinus

Anxiety and apprehension of the dental pain tends to avoid the dental treatment. As per the particular requirements of the patient, an ambit of local anesthetics drugs is customized to control the dental pain. Hence, gaining a perception of the aspect of local anesthetics and the knowledge to deliver anesthetic injection techniques correctly is an essential prospect of the Oral Surgery curriculum[1]. Every faculty should go through learning module schedule of the subject topics which is given for the SCORE Learning management system [LMS] module [2].

To live a healthy life style and be free from diseases, fruits must be incorporated in one’s daily food. Fruits are of high nutritional value and provide the body with the required daily allowance. They are highly perishable, but can be made into different products to make them available all year round. They can be processed into products which includes; fruit juice, jellies, marmalades, candies, fruit bars and jams. This study analyses jam produced using date powder and compared it with commercial jam produced using table sugar. The percentage compositions of the blends considered were 50%:50%; 70%:30%; 30%:70% of orange and apple pulps respectively with constant amount of date powder (50%). In addition to the pulp blends, 2.9% commercial pectin was added together with citric acid, and date powder. The entire mixture was heated at 120°C for 25 mins to enhance the viscosity of the blends. Proximate, microbial, physico-chemical analyses, sensory evaluation and Vitamin constituents of the experimental samples and the commercial jam were evaluated. The commercial jam was found best having higher scores in all the sensory parameters. However, in respect to proximate composition, the experimental samples had the highest in protein, ash, moisture, and fibre while the commercial jam only scored high in fat, carbohydrate. In respect to microbial count minimum fungal and bacterial growth, 1.00 cfu X 103 g-1 and 1.00 cfu X 105 g-1 respectively were recorded in the experimental samples at 3 weeks after production. The control sample had the highest value in vitamin A content (130.35mg/100g) and the least in vitamin C content (1.64mg/100g).The nutritional analysis and sensory evaluation obtained proved that the orange and apple jam samples made with date powder is a promising functional product which can be consumed by both young and adults.
Keywords: Orange; Apple; Date; Jam; Composite; Nutritional properties; Sensory analysis

Polyphenols are a large category of chemicals that include phenolic acids, flavonoids, and many other compounds. They have piqued the interest of both society and industry in food production. These chemicals are well-known for their antioxidant properties and potential health advantages, such as anti-inflammatory properties and the prevention of diet-related chronic diseases like cardiovascular disease, neurodegenerative disease, type 2 diabetes, and cancer. However, they have a low bioavailability, which limits their applicability due to their instability during digestion, which is caused by pH, enzymes, and interactions with other nutrients, among
other factors (Bamba et al., 2018).

Objective Confirm the exploratory factorial structure of an explanatory model of the conformation of community health networks before risk events.
Method Two non-experimental, cross-sectional and correlational studies were carried out with non-probabilistic selections of 107 students for the first job and 101 users of community health services for the second research, considering the professional practices and the social service of the first ones, as well as Access to services by the second group.
Results In the first study, the instrument was validated and in the second, the three dimensions reported in the consulted literature were confirmed.
Conclusion The design of the research limits the findings to the scenarios and the study samples, suggesting the extension of the work to other contexts for the contribution of empirical support to the proposed model.
Keywords: Governance; health; model; intervention; network

The present study investigated microbial diversity in the hindgut microbiota of Odontotermes obesus(Rambur). Colonies were isolated both aerobically and anaerobically by using tryptic soy agar medium. Isolates were characterized and identified by means of biochemical tests. Based on tentative identification, all the isolates belonged to the Enterobacteriaceae family. All the colonies were screened for cellulase, amylase and invertase activity. Enzyme assays were performed for positive colonies. The enzyme assay for amylase activity was found to be highest for strain No.16 at 1.46 the highest invertase activity was found in strain No.17 at 1.332 the enzyme assay for cellulase activity was found to be highest for strain No.12 at 0. 09 The results showed that termite gut bacteria play a significant role in biofuel production in terms of plant decomposition and conversion to simple sugars.
Keywords: Odontotermes obesus; Enterobacteriacae; cellulose; amylase; invertase

Ozone is a significant concern for our environment today. The ozone molecule, outside of the ozone layer, is Harmful to the air quality. It also affects humans in a wrong way. Various works are going on to stop the depletion of ozone.
A remarkable improvement was seen, which can predict ozone level three days ahead with accuracy up to 3 days advance. Random Forest and Multivariate Adaptive Regression Splines are some models used for research.
The new AI system developed could cause improved ways to regulate serious ozone problems and even contribute to solutions for global climate change issues. The research team used a singular loss function in developing the machine learning algorithm.
This could help make the planet secure.

Gene therapy is a fantastic new technology that has opened up a plethora of options to treat or prevent previously untreatable diseases. Gene therapy is the use of nucleic acids (either DNA or RNA) is used to  manipulate the genetic information of a patient’s cells. This is particularly helpful for diseases like Cystic Fibrosis where the ability to add a gene that makes the protein product the patient lacks or to just the gene itself is ideal. The addition of CRISPR-Cas for easier and more streamlined gene editing has also been a boon. However, the unfortunate truth is that despite decades of research, only a few gene therapies have made it to market. One of those reasons is the problems with carriers of gene therapy. For over three decades viral vectors were considered the go to for gene therapy carriers however they aggravate the immune system and can cause unwanted genotoxicity. This compromises their usefulness as a therapeutic treatment or preventative. So other methods of gene therapy carriers have been considered. Nanotech deliverers such as exosomes, gold nanoparticles, and others have shown great promise of being able to transport gene therapy with mitigated or no toxicity to the patient. This review will briefly go over both viral vector and nanotech non-viral vector alternatives to delivery of gene therapy.
Keywords: Gene therapy; nanotechnology; gene delivery; CRISPR; exosomes; viruses; magnetosomes

Transdermal drug delivery refers to the drug administration route through the skin that achieves the local or systemic treatment approved for clinical use. It is the third-largest drug delivery system after oral administration and injection. The advantages of the transdermal route are that the administration route of the drug is convenient and could reduce the fluctuation of blood drug concentration and toxic side effects. What is more, the drug could bypass the first-pass side-effect of the liver to prevent the drug from being destroyed in the gastrointestinal tract. Invasomes are new modified liposomes that differ from the liposomal vesicles in that they contain essential volatile oils, which are called terpenes. Also, ethanol in a low percentage is present in the vesicle either in the phospholipid layer or in the hydrous core. These modified newly discovered vesicles are intended to be used for topical and transdermal drug delivery due to their permeation effect and high deformability as compared to transferosomes.
Keywords: Invasomes; Transdermal drug delivery; phospholipids; terpenes; deformable vesicles

Design and use of enzyme inhibitors against viral enzymes is one of the new and effective ways to control viruses and treat viral infections, Enzyme inhibitors inactivate these enzymes by binding to the nucleotides functional groups of the virus vital enzymes, thus can directly disrupt the virus replication cycle and indirectly prevent the spread of viral infections by reducing and controlling the population and number of viruses, these inhibitors, on the one hand, inhibit the virus by filling and Occupying the active sites of the enzyme and on the other hand, they change the stereochemistry of the enzyme by binding to the structure of the enzyme, for this reasons, they are used as an effective and complementary drug in the treatment of infections and viral diseases. Human Immunodeficiency Virus (HIV) is a retrovirus because it has the reverse transcriptase enzyme. Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) are a class of Antiretroviral HIV drugs. Non- ucleoside Reverse Transcriptase Inhibitors (NNRTIs) block HIV reverse transcriptase enzymes by connecting to it. Tetrazole derivatives have strong antiviral activity against efavirenz and nevirapine-resistance viruses that have different genetic mutations. In this research, we study NNRTIs function and overview synthesis of 5-aryloxy- etrazole derivatives in the development path of NNRTIs.
Keywords: Anti-HIV Drugs; NNRTIs; Tetrazole; HAART; Retrovirus; Reverse Transcriptase Enzyme 

Therapeutic bioengineering is a rapidly growing discipline in medical science that combines biology and medicine with engineering principles to create products and methods that can tackle the widest range of a variety of medical and health-related issues in today’s society