A Rare Case of Cervical Cancer: Small Cell Neuroendocrine Carcinoma

Federica Zammit*, Silvaine Marie Dalli, Stephen Grima and Mark Sant
Department of Obstetrics and Gynaecology, Mater Dei Hospital, Msida, Malta
*Corresponding Author: Dr Federica Zammit, Basic Specialist Trainee in Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, Mater Dei Hospital, Triq Dun Karm. Msida, Malta.

Published: December 12, 2024

DOI: 10.55162/MCMS.08.262

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Abstract  

Small cell neuroendocrine carcinoma of the cervix (SCNECC) is an aggressive and rare malignancy accounting for less than 5% of cervical cancers. This case report discusses a 50-year-old woman presenting with vaginal discharge and spotting, later diagnosed with FIGO stage IIIc1 SCNECC. Histology confirmed HPV 18-associated small cell neuroendocrine carcinoma of the cervix, with imaging revealing pathological pelvic lymph nodes in the absence of distant metastasis . A multidisciplinary approach recommended chemotherapy and radiotherapy as the treatment strategy. The report underlines the diagnostic challenges, poor prognosis, and need for multimodal management while advocating for research into targeted therapies to improve outcomes.

Keywords: Small Cell Neuroendocrine Cervical Carcinoma; Cervical Cancer; Human papillomavirus; Imaging; Prognosis

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