Melanoma of the Anorectum: A Rare Entity - Case Report with Review of Literature
Gurpreet Kaur1*, Renu Madan2, Paresh Singhal3 and Ankur Ahuja4
1Associate professor Armed Forces Medical College Pune
2Professor and Head of Department, Dept of Pathology Institute of Naval Medicine, INHS Asvini
3Associate professor Armed Forces Medical College Pune
4Professor Armed Forces Medical College Pune
*Corresponding Author: Gurpreet Kaur, Associate Professor, Armed Forces Medical College, Pune.
Published: February 05, 2024
An uncommon form of malignant melanoma is anorectal malignant Melanoma (ARMM), attributing to only 1% of all rectal malignancies. About There are times when the diagnosis appears straight forward, and at other times it is confusing thereby requiring a high degree of suspicion on the part of the treating physician. Due to the aggressive nature of this disease, an early diagnosis and prompt treatment are essential. Specific mutations in the c-Kit/stem cell factor (SCF) pathway, the endothelin receptor type B/endothelin pathway, and the Sox10transcription factor are being incriminated in the pathogenesis pigment and enteric nervous system disorders including melanomas. This may form a basis for further research and treatment of these disorders.
Keywords: Anorectal Melanoma; aggressive; Ckit/stem cell factor (SCF) pathway