Effects of Postinor use on Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Prolactin and Progesterone Serum Levels

Airhomwanbor KO¹, Iyevhobu KO²*, Idehen CI³, Akhile AO¹, Omolumen LE¹, Akhere PI⁴, Asibor E³, Ohenhen JE⁵ and Oseghale W^1
1Department of Chemical Pathology, Faculty of Medical Laboratory Science, Ambrose Alli University, Ekpoma, Edo State, Nigeria
²National Open University of Nigeria, Uromi Community Study Centre, Uromi, Edo State, Nigeria
³Department of Histopathology, Faculty of Medical Laboratory Science, Ambrose Alli University, Ekpoma, Edo State, Nigeria
⁴Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria
⁵Department of Medical Laboratory Science - Haematology, Edo State University, Uzairue, Edo State, Nigeria
*Corresponding Author: Iyevhobu Kenneth Oshiokhayamhe, National Open University of Nigeria, Uromi Community Study Centre, Uromi, Edo State, Nigeria.

Published: July 14, 2023

DOI: 10.55162/MCMS.05.143

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Abstract  

Postinor-2, also known as the ‘morning after pill’, is used as an emergency contraceptive. The aim of the study is to evaluate the effects of Postinor on FSH, LH, prolactin and progesterone serum levels on female albino rats. The experimental animals were separated into five groups (A - E). Each group contains ten rats each (n = 10) using 5 big cages to house them. Group A served as the control, while groups B - E served as the test groups. The administration of postinor was given orally as follows: Group A (Control) received only normal feed (growers’ mash) and distilled water daily for four weeks. Group B were administered with 1ml of 1.5mg/100ml of postinor, Group C were administered with 2ml of 1.5mg/100ml of postinor, Group D were administered with 3ml of 1.5mg/100ml of postinor, Group E were administered with 4ml of 1.5mg/100ml of postinor. Determination of serum progesterone, prolactin, FSH and LH was done using ELISA TECO kit. The result, Mean and SD of FSH, LH, prolactin and progesterone serum levels on female albino rats on Postinor, in which FSH for control was 6.733±2.3485 while that of the test was 2.3485±.77746. For LH, the control was 11.5667±.77746 while that of the 1.3939±74075. For the prolactin, the control was 8.2778±.42426 while the test group was 15.7455±4.23896. For the Progesterone, the control was 0.8167±.42426 while the test was 1.5109±.36281. However, a statistically significant (P<0.05) decrease was observed for the FSH and LH of test group administered with postinor while an increase was observed for the Prolactin and Progesterone levels of the test group when compared with the control. In conclusion, this present study concludes that no significant changes was observed in the body weight of all groups and Group B to E were administered with small and large doses of postinor showed significant variations.

Keywords: Postinor; Postinor; Follicle Stimulating Hormone (FSH); Luteinizing Hormone (LH); Prolactin and Progesterone