Changes in Brain Tissue Following Administration of Adipose-Derived Stem Cells

Yohei Yamashita¹* and Taisaku Shozaki^2
1Organization for General Education, Momoyama Gakuin University, Osaka, Japan
²Go Department of Neurosurgery, Fukuoka, Japan
*Corresponding Author: Yohei Yamashita, Organization for General Education, 1-1 Manabino, Izumi-shi, Osaka, Japan.

Published: May 26, 2023

DOI: 10.55162/MCMS.04.130

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Abstract  

     Introduction It is estimated that the number of dementia (Alzheimer's disease) patients worldwide will reach 16.2 million by 2050, and urgent measures are required. Prevention of dementia must continue from childhood to old age, and behavioral changes in lifestyle are important.

     At present, there is no effective method for all stages of Alzheimer's disease from the pre-MCI stage to all stages of Alzheimer's disease. In this study, we focused on autologous tissue regeneration of adipocyte-derived stem cells to investigate an effective method for all stages of Alzheimer's disease from the pre-MCI stage.

     Adipocyte-derived stem cells have the ability to differentiate into various cell types and are expected to be applied to tissue regenerative medicine.

     Therefore, we investigated whether adipocyte-derived stem cells are effective for all brain atrophy.

     Methods 5-10 g of subcutaneous adipose tissue was collected from the abdomen of the subjects, and mesenchymal stem cells were isolated and cultured from the adipose tissue. The cultured autologous adipocyte-derived stem cells were administered intravenously to the subjects and evaluated by VSRAD until 1, 2, 3, 4, and 5 months after administration.

     Results Both subjects (n=2) showed a trend toward maintenance or improvement as analyzed by VSRAD.

    Conclusion In this study, except for the administration of adipocyte-derived stem cells, the subjects were only instructed to maintain their previous lifestyle, and the number of subjects was small, so it is not possible to determine the effect of the treatment.

     However, the fact that improvement in brain atrophy was observed is a new finding.

Keywords: Alzheimer's disease; mild cognitive impairment; VSRAD; Autologous adipocyte-derived stem cells; regenerative medicine