Prognostic Analysis of Chronic Lymphocytic Leukemia
Pushpam Kumar Sinha*
Independent Researcher, 101, Vijayshree Complex, Kankarbagh Main Road, Kankarbagh, Patna, India
*Corresponding Author: Pushpam Kumar Sinha, Independent Researcher, 101, Vijayshree Complex, Kankarbagh Main Road, Kankarbagh, Patna, India.
Published: March 31, 2023
DOI: 10.55162/MCMS.04.122
Abstract
Chronic Lymphocytic Leukemia (CLL) is the most common type of blood cancer to be found in adults. It mostly arises when genetic/epigenetic abnormalities accumulate in those cells of the bone marrow that are destined to become B cells. Though this disease may start in bone marrow, at a later stage it moves to the blood. This disease is not often so lethal as the other types of cancers. Based on the aggressiveness of the disease, CLL patients may be classified into three types: little greater than 33% (of the patients) are non-aggressive (NA-CLL), little less than 57% are partly aggressive (PA-CLL), 10% are aggressive (A-CLL) [4]. A NA-CLL patient of a particular age lives so long as the healthy individual of same age. A PA-CLL patient develops the disease slowly over a period of 5-10 years, after which the PA-CLL patient transforms to the A-CLL patient. The A-CLL patient lives up to a maximum of 3 years. The pathogeneses of the disease and the transcriptional signatures of the CLL cells are different in different compartments [5]. The CLL cells have been found residing in the following three compartments: the bone marrow (BM), the peripheral blood (PB), and the lymph node (LN). This editorial is focused on the prognostic data of paper [5], in the context of CLL. The paper [5] has studied the transcriptional dissimilarities and similarities of CLL cells in only the two compartments, PB and LN.