Chronic Neuroinflammatory Cycle: Potential target to halt the Progression of Neurological Disorders
Prashant Tarale
Published: September 24, 2021.
Abstract
Neurological and neurodegenerative diseases have become a major social and economic burden worldwide with more individuals predicted to be affected in coming decade. Therefore, understanding the neuropathological mechanism and identifying the promising target for intervention has become an active area of research in neurodegeneration. The chronic neuroinflammation has considered to be fundamental mechanism causing progressive loss of dopaminergic neurons as observed in clinical course of various neurodegenerative diseases. Microglial proliferation and activation are the hallmarks of several neurological disorders.