Heterotransplantations and Genomic. The Asterias Rubens Sea Star Axial Organ (a.o) Cells, the Sea star Igkappa Gene: Effects against Malignant Vertebrate Cells. Preliminary Review.
Michel Leclerc
Published: September 01, 2021.
Abstract
We performed in 1975, the first heterotransplantation of invertebrate A.O in nude mouse, then a double heterotransplantation of human tumor and axial organ next to this last one, always in nude mouse: The human tumor was rejected in 50% of observed cases. Some years later, we found that A.O cells exerted an induced and spontaneous cytotoxicity against SP2 and MBL2 mouse tumoral cells. Recently, we discovered a sea star Igkappa gene with immune properties. This gene was inserted in a CMV (cytomegalovirus) and finally in a plasmid called « young » plasmid.
The induced « young » protein exerted a spontaneous cytotoxicity against osteosarcom cells (U2oS cells) against A-375 melanome cells and Hela cells.