An update on the Epidemiology, Diagnosis and Management of the Reemergent Life Threatening Scrub Typhus
Kulvinder KocharKaur, Gautam Allahbadia and Mandeep Singh
Published: March 07, 2022
Abstract
Scrub typhus represents a robust Public Health ailment that is Prevalent in the Asia-Pacific region that is inclusive of although not restricted to Korea, China, India, Taiwan Indonesia, Thailand, Sri Lanka, as well as the Phillipines, This area has been referred to as the tsutsugumashi triangle. One billion people have a threat globally to get afflicted, that results in a disease generation in one million individuals. Scrub typhus alias tsutsugumashi disease occurs every year. Here we have stressed on the epidemiology world wise besides the significance of Scrub typhus in Indian scenario that presents as an acute febrile illness having life threatening consequences. We conducted a Here we conducted a systematic review utilizing search engine pubmed, google scholar; web of science; embase; Cochrane review library utilizing the MeSH terms like Scrub typhus; other rickettsios is; differential diagnosis with other acutefebrile illnesses; epidemiology of Orientiatsutsugumashi (etiologic agent); malaria; Indian scenario; Leptrombidiumbitesllarvae; mites; serology; WeilFelix reaction; immuofluoresceceassay; met genomic next generation sequencing (mNGS), Scrub typhus cell surface display technology; treatment; doxycycline; azithromycin; rifampicin; chloramphenicol; innovative early diagnostics. We found a total of 3500 articles out of which we selected 51 articles for this update. Nometa-analysis was done. Since this disease has reemerged it is usually not kept in mind as a differential diagnosis in acute febrile illnesses that is why we chose to review and update this life hreateningisease having central nervous system (CNS), Gastrointestinal Tract (GIT), complications, myocarditis, besides usually diagnostic eschar. Avoidamce is equally important specifically for farmers other vegetation areas etc.
Keywords: Scrub typhus; epidemiology; complications; avoidance; Public Health problem