Switch and Variance-Warthin’s Tumour
Anubha Bajaj*
Published: October 29, 2022
Abstract
Warthin’s tumour is a benign salivary gland neoplasm commonly incriminating parotid gland. Tumefaction enunciates cystic configurations coated with a dual epithelial cell layer with subjacent dense, lymphoid stroma. Additionally designated as papillary cystadenoma lymphomatosum papilliferum or adenolymphoma, Warthin’s tumour is frequently expounded and follows pleomorphic adenoma in frequency. Generally, Warthin’s tumour occurs due to incorporation of lymphoid tissue within the parotid gland. Alternatively, inflammatory infiltrate may induce cystic and oncocytic modifications within pertinent salivary gland. Neoplasm may be concordant with tubercular infection induced by Brucella mellitensi [1, 2]. Warthin’s tumour is a non clonal, diploid neoplasm. However, neoplasms concurrent with muco-epidermoid carcinoma appear associated with chromosomal translocation t(11;19) and fusion transcript of CRTC1/MAML2 genes. Besides, deoxy-ribonuclease (DNA) of human herpesvirus 8 (HHV8) may accompany Warthin’s tumour [1, 2].
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