Symetric Triplane Complexes Based on Porphyrins and Phtalocyanines with Earth Rare Metals of Type: [(Po) Ln(Pc) Ln (Po)] for Application in Medical Imaging

Mohamed Tahiri¹* and Abdelkrim Boumegnane^1,2
1Organic Synthesis and Extraction Laboratory (OSEV), Ain Chock’s Faculty of Sciences, Hassan II University, Km 8 Route d'El Jadida, B.P 5366 Maarif 20100. Casablanca, Morocco
²Textile Materials Research Laboratory (REMTEX), Higher School of Textile and Clothing Industries (ESITH), 20230 Casablanca, Morocco
*Corresponding Author: Mohamed Tahiri, Organic Synthesis and Extraction Laboratory (OSEV), Ain Chock’s Faculty of Sciences, Hassan II University, Km 8 Route d'El Jadida, B.P 5366 Maarif 20100. Casablanca, Morocco.

Published: April 22, 2024

DOI: 10.55162/MCET.06.207

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Abstract  

Paramagnetic complexes of transition metals and rare earths have attracted a lot of interest in the last year in medical imaging. Indeed, the study by ¹H NMR spectroscopy has revealed that these agents increase the contrast between an affected cell and a normal one in biological tissues. This increase in contrast is due to the decrease in the nuclear relaxation time of the ¹H proton of water. Due to their high magnetic moment, the dipolar interactions between these agents and water molecules are strong, which mainly reduces the nuclear relaxation time of ¹H protons. Bloch was the first to use ferric nitrate as an agent of observation.

Synthetic mixed triplane complexes containing functionalized outer porphyrins and an inner phthalocyanine were prepared and their conditions of obtaining with better yield were studied. These complexes were characterized by UV/Vis. spectroscopy, H NMR mass spectrometry. In the second part we have reported the different strategies of interporphyrin coupling and the appropriate method for obtaining the "cage" complex in which a phthalocyanine ligand is encapsulated by two external porphyrinate ligands. The different parameters that govern this kind of systems are exposed.

Keywords: Meso-tetra.para-propargylphenylperphynate (Tp-PrOP) P; Meso tetra-para-aminophenylprophyrinate (Tp-H2NP) P; Phtalocyanine; octamethyl phtalocyaninate (Pc(Pme); octamethoxyphtalocyaninate (PcMe8); Ln= La; Ce; Gd

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